Ying Ge

Dr. Ying GeDirector of Mass Spectrometry Core Facility
Ph.D. 2002, Cornell University

Contact Information
Email: yge@physiology.wisc.edu
(608) 263-9212 Phone
(608) 265-5512 Fax

Research Interests

Develop and apply cutting-edge mass spectrometric technology to biomedical research:

  1. Top down proteomics in the cardiovascular and other biomedical systems
     
  2. Characterization of complex post-translational modifications by high resolution tandem mass spectrometry
     
  3. Discovery, characterization and validation of biomarkers associated with human disease

Presentations

  • Ge, Y.; Zhao, D.; Gu, X.; Lemoff, A.S.; Ding, X. Rapid Determination of Disulfide Bonds in Large Proteins by Top Down Liquid Chromatography Tandem Mass Spectrometry 54th Conf. Mass Spectrom. Allied Topics, Seattle, WA, 2006 (Poster)
     
  • Grant, J. E.; Vestling, M. M.; Walker, J. W. Phosphorylation of the Cardiac Contractile Apparatus by PKC-β2 Evaluated by Stable Isotope Labeling 54th Conf. Mass Spectrom. Allied Topics, Seattle, WA, 2006 (Poster)
     
  • Ge, Y.; Walker, J.W.; Gumerov, D.R.; Easterling M.L.; Speir, J.P. Localization of Phosphorylation Sites in Human Cardiac Troponin I by Top Down Electron Capture Dissociation Mass Spectrometry HUPO 5th World Congress, Long Beach, CA, 2006 (Oral)

Selected Publications

  1. Ge, Y; Lawhorn, B. G.; ElNaggar, M.; Sze, S. K.; Begley, T. P.; McLafferty, F. W. Protein Oxidation in Viral Prolyl-4-hydroxylase Characterized by Top Down High Resolution Tandem Mass Spectrometry Protein Science 2003, 12, 2320-2326
     
  2. Ge, Y.; ElNaggar, M.; Sze, N.; Han Bin Oh, Begley, T. P.; McLafferty, F. W.; Boshoff, H.; Barry, C. B. Top Down Characterization of Secreted Proteins from Mycobacterium Tuberculosis by Electron Capture Dissociation Mass Spectrometry J. Am. Soc. Mass Spectrom. 2003 14, 253-261
     
  3. Sze, S. K.; Ge, Y.; Oh, H.; McLafferty, F. W.; Top Down Mass Spectrometry of a 29 kDa protein for Characterization of Any Posttranslational Modification to Within One Residue Proc. Natl. Acad. Sci. U. S. A.,2002, 99, 1774-1779.
     
  4. Ge, Y; Lawhorn, B. G.; ElNaggar, M.; Strauss, E.; Park, J-H.; Begley, T. P.; McLafferty, F. W. "Top Down" Characterization of Larger Proteins (45 kDa) by Electron Capture Dissociation Mass Spectrometry J. Am. Chem. Soc. 2002, 124, 672-678
     
  5. Xi, J; Ge, Y.; Kinsland, C. L.; McLafferty, F. W.; Begley, T. P. Biosynthesis of the Thiazole Moiety of Thiamin in Echeriachia Coli : Identification of a Novel Acyldisulfide Linked Protein-protein Conjugate that Is Functionally Analogous to the Ubiquitin/E1 Complex, Proc. Natl. Acad. Sci. U. S. A., 2001, 98, 8513-8518.
     
  6. Ge, Y; Horn, D. M.; McLafferty, F. W. Blackbody Infrared Radiative Dissociation of Larger (42 kDa) Multiply Charged Proteins, Int. J. Mass Spectrom, 2001, 210/211, 203-214.
     
  7. Horn, D. M. Ge, Y. McLafferty, F. W. Activated Ion Electron Capture Dissociation for Mass Spectral Sequencing for Larger (42 kDa) Proteins, Anal. Chem. 2000, 72, 4778-4784.