Core Facility

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Facility Sign-up Calendars:
http://labs.wisc.edu/hpp/

Core facilities of the Human Proteomics Program are dedicated to the needs of UW Medical School researchers with specific emphasis on understanding disease and discovery of biomarkers associated with human disease. A biomarker in this context is a detectable and reproducible change in a tissue or body fluid that represents the presence of disease or potential for disease of virtually any origin, i.e., lifestyle, chronic, genetic, infectious, etc.

The Human Proteomics Program will be made up of two interdependent core facilities:

  1. Mass Spectrometry
  2. Bioinformatics

The primary technology for data acquisition will be Mass Spectrometry due to its combination of general applicability to a vast array of biological molecules, unprecedented sensitivity and reliability for detection of those molecules, and potential for creating new frontiers in research and diagnostics.

The foundation of the Mass Spectrometry Core Facility will initially consist of three modern mass spectrometers capable of covering a range of experimental and diagnostic applications. Instrumentation in this facility will complement existing instrumentation and expertise on campus, and will include robotics for sample handling and high resolution protein chromatography.

An essential component of any proteomics program is state-of-the-art bioinformatics capabilities including statistical and cluster analysis, data mining, data archiving and database management analogous to those widely used in microarray studies on campus. The precise computing infrastructure required for Bioinformatics will depend upon the specific software accompanying commercial spectrometers, and will be extended and customized by software development within the program.

Photo Gallery

FTarrival
The arrival of the new Bruker 12 T mass spectrometer

Staff Office
The arrival of the new Bruker 12 T mass spectrometer

Training
FT-ICR training session

TOF
Instrument room for maXis II and impact II Q-TOF

LTQ/FT Installation
LTQ/FT Installation

LTQ
LTQ

FT
FT

Wet Lab
Wet Lab

Staff Office
Staff Office